PrEP -- Pre-Exposure Prophylaxis
Highly effective HIV prevention
PrEP is over 99% effective at preventing HIV when taken consistently
PrEP tablets have NO interactions with recreational drugs
Truvada and Descovy (tenofovir/emtricitabine) are NRTIs that are not metabolised by CYP enzymes. This means recreational substances do not affect how PrEP works. Your PrEP keeps working.
What is PrEP?
PrEP (Pre-Exposure Prophylaxis) is a medication that prevents HIV infection before potential exposure. It is one of the most effective HIV prevention tools available and has transformed sexual health for millions of people worldwide.
PrEP is for anyone who may be at risk of HIV -- regardless of gender, orientation, or reason. There is no shame in protecting yourself and your partners.
PrEP Options
Daily Pill
Take one pill every day at roughly the same time. Truvada or Descovy are the most commonly prescribed. Reaches full protection after about 7 days of daily use for anal sex, and about 21 days for vaginal sex.
Event-Based Dosing (2-1-1)
Also known as “on-demand” PrEP. Take 2 pills 2--24 hours before sex, then 1 pill 24 hours after the first dose, then 1 pill 24 hours after that.
- 2 pills -- 2 to 24 hours before sex
- 1 pill -- 24 hours after the first dose
- 1 pill -- 24 hours after the second dose
Note: Event-based dosing is only evidence-based for cisgender men and trans women having anal sex. Consult your provider for other situations.
Injectable PrEP
Cabotegravir (Apretude) is a long-acting injection given every 2 months. No daily pills required. It is as effective as daily oral PrEP and may be a good option if you prefer not to take pills.
How to Access PrEP
PrEP is available through:
- Sexual health clinics
- Your GP / primary care provider
- Online PrEP services (in many countries)
- Community health organisations and LGBTQ+ centres
In many countries, PrEP is free or subsidised. In the US, most insurance covers PrEP, and patient assistance programmes exist for those without insurance. In the UK, PrEP is free through the NHS. In the Netherlands, PrEP is covered by health insurance.
On other HIV medication?
Check ARV interactions with recreational drugs